Ageloc, by Nu Skin coming in October 2008 Have you ever wondered why some people look much younger then they really are? Nu Skin's AgeLoc technology has the answer. Hi, this is Kathy in Las Vegas. I have always taken great care to protect my skin by moisturizing and staying out of the sun as much as possible. But between living in the very dry air in Las Vegas and being in my mid-forties I was looking for a non-surgical solution to keeping my skin looking young. A business associate of my husband introduced me to the Galvanic Spa skin treatment system by Nu Skin. I have been using the Galvanic Spa now for 2 months and the results have been amazing to me. Just when I thought the treatments could not get any better, Nu Skin announced a new revolutionary product being released this October called "ageLOC". I believe AgeLoc is the most exciting discovery to hit the anti-aging industry to date. AgeLoc is a discovery that will once again demonstrate Nu Skin's outstanding forward position in the anti-aging market. We know that exposure to the sun and pollutants can cause free radical damage and accelerated aging, but even many who try to avoid the aging effects of the sun still feel they may be showing more signs of aging than they should. So what is it that makes some people look naturally young for their age? Nu Skin has unlocked the science behind their secret— Although the skin care industry has made some significant progress toward the correction and prevention of the visible signs of aging, there are still many unknown factors regarding why we age—and why we all seem to age differently. The effects of the sun and the environment are fairly well understood and highly effective sunscreens exist to help us avoid the aggressive aging effects of ongoing exposure. Less understood are the biological or intrinsic processes that affect our appearance over time. Recently, scientists at Purdue University in collaboration with Nu Skin Research and Development, have discovered a new and potentially significant internal source of aging—an enzyme called arNOX. Present on the surface of our cells, this enzyme is capable of generating skin damaging free radicals in the epidermis around the clock. Mostly inactive in our youth, activity levels of arNOX increase as we age and vary by individual. Together with Purdue University Nu Skin has discovered a previously unknown internal source of aging, this source of internal aging is capable of generating free radicals in the epidermis around the clock. So unlike exposure to the sun, there is nowhere to hide from these damaging effects. More free radicals can mean more damage to your skin— which causes lines, wrinkles, sagging skin, discoloration and hyper-pigmentation, many of the visible effects of aging. Only Nu Skin has an exclusive…Patent pending technology to target that source of aging, helping you control your skin's genetic destiny… and it's coming this Fall! ageLOC ingredients have been shown to prevent the expression of free radicals associated with the arNOX enzyme. This prevention may help slow the signs of aging that may be caused by accelerated free radical production. The first product with ageLOC will pre-launch at the Nu Skin North American Convention this October and will be available in the Galvanic Spa® Facial Gels. So, not only will you get all of the immediate results from using the Galvanic Spa, you will also slow the external visible signs of aging at the very source. In the next couple months, I will share with you the secret to controlling your skin's destiny! This is Kathy again. Let's talk reality with no hype. The ageloc and Galvanic spa products are sold through Nu Skin. I am a Nu Skin distributor and business builder. Nu Skin has been around since 1984 and is experiencing the largest growth ever with the Galvanic Spa and other skincare anti-aging products including the new products with ageLOC. I am not a network marketer by trade. My husband and I are successful concert producers. I was not motivated to sign up due to any promises of riches or fame. I tried the products as a customer. After using the products, the person who introduced us to Nu Skin showed me a way I could not only buy wholesale, but also get my products for free just by sharing the Galvanic Spa to others who want to slow down the aging process. Now I am a business builder serving the entire Southwest and abroad. Whether you want to be "in the business" or not and if you care about your skin's appearance, let me introduce you to the product line. Once you fall in love with the product line, and if you eventually want to get your product for free or maybe even earn a great income I will be here you show you the way to be a business builder like me. Please call me or my husband Chris at 702-942-3309 or e mail me for more information. You can also follow this link to see videos and read more about the Galvanic Spa and the soon to be released ageLOC product line. Though we serve the world market with Nu Skin products, if you live in the Las Vegas area we would love to meet with you immediately so I can demonstrate the Galvanic Spa and  introduce you to the ageLOC technology when it is released in October. If you would like to immediately purchase the Galvanic Spa click here. If you would like to sign up and build a Nu Skin Business as well, please click here. Details on skincare and the anti-aging process on the skin: Essential Needs of the Skin The skin has up to 10 essential needs for optimal health and beauty. Determining and meeting your skin’s essential needs with a comprehensive skin care regimen is critical to maintaining the healthy function and beautiful appearance of the skin. Synergistic Approach to Skin Care The best skin care products are designed to work synergistically to meet the essential needs of the skin. As they do this, they maintain and enhance the health and natural beauty of the skin. Essential Needs of the Skin The skin’s 10 essential skin care needs can be divided into two categories: Basic needs—the minimum, daily needs or regimen steps all skin types require. Advanced needs—met by incorporating additional regimen steps, as needed, to address specific concerns. Starting in our late 20s, our advanced needs steadily increase. Together, basic needs and advanced needs form the essential needs of the skin. Advanced Needs When specific skin concerns exist, such as discoloration, free radical damage, and aging, addressing these concerns is critical for skin health and beauty. Incorporating regimen steps to target the skin’s advanced needs gives your skin the needed advantage of advanced skin care. Advanced Need: Revitalize Fatigue and stress can make the skin appear dull and lifeless. The essential step revitalize helps restore vibrancy by increasing circulation to the skin. The advanced need, revitalize, should be met two to three times per week. Galvanic Spa treatments are one way to help revitalize the skin. Spa Results at Home Clients who have a professional galvanic treatment may spend from to $90 to $200 per treatment. These treatments may be done once or twice a month, making it a very expensive, infrequent, and inconvenient way to get the benefits of galvanic treatment. Introducing Nu Skin® Galvanic Spa™ II System The exclusive Galvanic Spa System II from Nu Skin is a programmable device with patented self-adjusting galvanic current and interchangeable heads for the face, scalp, and body. The Galvanic Spa works synergistically with specially formulated products to facilitate transport of key ingredients—delivering revitalizing, restorative, and rejuvenating benefits. Nu Skin Galvanic Spa System brings all of the benefits of a spa galvanic treatment into the ease and comfort of your own home. What Is a Galvanic Treatment? For more than 50 years, spa and salon professionals have used gentle galvanic currents in customized treatments to refresh and energize the skin. These treatments, through a gentle massaging action, help to focus cellular energy and enhance circulation. How Does a Galvanic Treatment Work? Like charges repel each other and opposites attract. By formulating products to contain a specific charge and using currents of the same charge, the currents are able to “push” the product into the skin, which facilitates the delivery of key ingredients. With the careful application of positive and negative galvanic currents to the face, an aesthetician is able to perform a variety of skin treatments. A negative galvanic current encourages the transport of water-soluble mixtures, whereas a positive galvanic current aids in the removal of toxins and impurities. Nu Skin® Galvanic Spa™ II System Benefits Nu Skin Galvanic Spa II System was developed to provide: Self-adjusting currents. Interchangeable heads. Flexible timing. User selectable polarity. An affordable option to spa treatments. Convenience. Enhanced delivery of key ingredients. Nu Skin® Galvanic Spa™ Face Gels with NEW ageLOC™ Technology Restores and Protects Skin’s Youthful Radiance Galvanic Pre-Treat Gel and Treatment Gel remove impurities while reviving and invigorating your skin. Nu Skin Galvanic Spa Facial Gels now feature new ageLOC technology—a proprietary blend of ingredients that help slow the signs of aging at their source. Treatment Gel with ageLOC™ Key Ingredients: Proprietary ageLOC blend—helps slow free radical production at its source and inhibits the visible signs of aging. Arginine—an amino acid which helps the skin to recover from stress. Magnesium—a necessary component that promotes cellular energy. Treatment Gel with ageLOC™ Description of Benefits a) Formulated with ageLOC technology—a revolutionary anti-aging ingredient blend. b) Facilitates recovery from stress; promotes cellular energy. Arginine is an amino acid involved in the relaxation of small blood vessels, leading to increased circulation. Arginine facilitates recovery from stress—caused by free radicals, lack of nutrients, build up of toxins, etc.—and injury. Magnesium is an essential mineral and key compound of mitochondrial function. Mitochondria are the organelles of tiny organs within skin cells that produce cellular energy. c) Enhances skin hydration and leaves skin feeling incredibly soft, clean, and refreshed. Formulated with gentle humectants for skin hydration, while rose, sandalwood, and jasmine extracts revive the skin and leave it feeling refreshed Companion Products: Tru Face® Essence Ultra—a facial contouring serum that contains the patented anti-aging ingredient Ethocyn®, which helps restore definition and firmness to the skin, and an antioxidant network to protect skin proteins. Tru Face® Line Corrector—features a revolutionary pro-collagen peptide that helps soften moderate to deep lines around the mouth, eyes, and forehead. Use with the Galvanic Spa for enhanced benefits. Nu Skin 180°® Anti-Aging Skin Therapy System—designed to reverse the appearance of a full range of aging effects, each product in this system plays an integral role in delivering anti-aging benefits and works synergistically to enhance results. "Why some of us look younger or older than we are" A Stanford Clinical Bulletin Background Although the skin care industry has made some significant progress toward the correction and prevention of the visible signs of aging, there are still many unknown factors regarding why we age—and why we all seem to age differently. The effects of the sun and the environment are fairly well understood and highly effective sunscreens exist to help us avoid the aggressive aging effects of ongoing exposure. Less understood are the biological or intrinsic processes that affect our appearance over time. Recently, scientists at Purdue University in collaboration with Nu Skin Research and Development, have discovered a new and potentially significant internal source of aging—an enzyme called arNOX. Present on the surface of our cells, this enzyme is capable of generating skin damaging free radicals in the epidermis around the clock. Mostly inactive in our youth, activity levels of arNOX increase as we age and vary by individual. To learn more about how a person’s arNOX activity levels might correlate to their real or perceived age, in 2006 Nu Skin collaborated on a research study with Purdue University and the Stanford School of Medicine. The results will be presented at the 25th International Federation of Societies of Cosmetic Chemists Congress to be held in Barcelona, Spain in October 2008. Study Title A Randomized Pilot Study of the Relationship between arNOX Levels and Appearance of Aging Skin Participants : 25 females, ages 45-65 Methods Using a VISIA complexion analysis machine, close-up images of the faces of twenty five women between 45 and 65 years of age were taken and analyzed. Assessments were made of key indicators of aging skin such as wrinkles, pore size, evenness of color, porphyrins, and UV spots. A panel of independent clinical skin graders reviewed the close-up photographs taken by the VISIA and estimated each participant’s chronological age based on the condition of their skin. The professional panel estimated ages were averaged for each subject, and then compared to subject’s actual age. The arNOX enzyme activity levels from each test subject were determined by drawing blood samples which were then processed and analyzed at Purdue University. Finally, researchers compared and correlated each participant’s professionally estimated chronological skin age and real age with the arNOX activity levels in the blood. Results According to preliminary data, a correlation exists between arNOX activity levels and errors in estimating participants’ chronological skin ages as estimated by professional graders. In other words, the apparent visible ages of those with higher arNOX activity levels were estimated to be an average of seven years older than their chronological age while the apparent visible ages of those individuals with lower arNOX activity levels were estimated to be an average of seven years younger than their chronological age. This suggests that low activity levels of arNOX may result in looking visibly younger—as we get chronologically older. -------------------------- From the National Institutes of health: Aging-related cell surface ECTO-NOX protein, arNOX, a preventive target to reduce atherogenic risk in the elderly. Morré DJ, Morré DM. Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA. morre@pharmacy.purdue.edu A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the terminal oxidases. The ECTO-NOX proteins of the cell surface have been postulated as well to link the accumulation of lesions in mitochondrial DNA to cell surface accumulations of reactive oxygen species as one consequence of their role as a terminal oxidase in a plasma membrane electron transport chain. Of the several ECTO-NOX proteins now known, one is a novel cell surface form (arNOX) associated with lymphocytes, sera, saliva and perspiration of patients of age 50 or older and is capable of directly reducing ferric cytochrome c through the generation of superoxide. Because of their cell surface location, ECTO-NOX proteins capable of superoxide generation in response to aging would serve to propagate the aging cascade both to adjacent cells and to oxidize circulating lipoproteins. The generation of superoxide associated with aging is inhibited by coenzyme Q10. As such, the findings provide a rational basis for the antiaging activity of circulating coenzyme Q10 in the prevention of atherosclerosis and other aging-related oxidative changes in cell membranes and circulating lipoproteins. ----------- arNOX is a destructive enzyme discovered by Nuskin scientists in collaboration with scientists at Purdue University. This too is ground-breaking. arNOX is located on skin cells and generates free radicals on the skin surface. Free radicals destroy collagen and elastin. The higher the arNOX serum levels, the older you look and the faster you age. Nuskin scientists are developing a blend of ingredients that will inhibit the arNOX enzyme! These ingredients will be blended into the galvanic gels and introduced at the convention in Salt Lake City, Oct. 22-25, 2008. We will be attacking a major cause of skin aging, not just treating the effects of aging. Do you realize the opportunity for us with this alone and how it will shake up the skin care industry? Here is the press release on arNOX last week: KYOTO, Japan, May 14, 2008 /PRNewswire-FirstCall via COMTEX/ -- New research funded by Nu Skin Enterprises on internal causes of aging has identified a previously unknown source of superoxide free radicals. Free radicals from external triggers, such as sun exposure and cigarette smoke, have long been known to damage skin cells and components of the skin's extracellular matrix, including collagen and elastin. Scientists from Nu Skin Enterprises and Purdue University report their novel research findings on age-related NADH oxidase (arNOX) this week in Kyoto, Japan, at International Investigative Dermatology 2008 (IID2008), a major scientific venue for the latest information on skin biology. The scientists present compelling evidence that arNOX, an enzyme associated with cell membranes, is present and active on skin cells. Significantly, arNOX activity increases during the "aging" years of about 45-70. "Identifying skin-associated arNOX and its increasing activity with age is a breakthrough discovery in understanding skin aging," said Zoe Diana Draelos, MD, primary investigator with Dermatology Consulting Services, member of the Nu Skin Scientific Advisory Board and one of the study authors. "Currently, most dermatological research focuses on correcting skin damage after it occurs. Identifying an internal source of free radicals in skin, and advancing an understanding of how and why they are generated, adds to our ability to address fundamental mechanisms that may combine with external sources to lead to accelerated skin aging." "Evidence of arNOX in the skin provides further insights into potentially revolutionary therapies for skin care, particularly because its activity correlates with the ages when people begin to see their skin lose its elasticity and firmness, and notice more discoloration and lines and wrinkles," remarked Helen Knaggs, PhD, vice president of Nu Skin global research and development. "If we can develop innovative ways to inhibit arNOX activity and prevent the production of free radicals in the first place, then we can address both sides of the equation -- correcting free radical damage from external sources, while at the same time preventing free radical production from internal sources." Authors of the study are Dale Kern, senior scientist for Nu Skin Enterprises; Dr. Draelos; Dorothy Morre, PhD, professor of foods and nutrition, Purdue University; and D. James Morre, PhD, Dow distinguished professor of medicinal chemistry, Purdue University. Nu Skin has funded ENOX research by the Morres since 1999. About arNOX The arNOX enzyme is one in a class of newly-identified ECTO-NOX (external NADH oxidase or ENOX) proteins that are located on external cell membranes. ECTO-NOX proteins become increasingly active to generate additional metabolic energy as cell mitochondria age and produce less energy. arNOX has been identified in all cells tested, including serum and saliva and now the dermis and epidermis. Its unique property is that it generates superoxide at the cell surface that is capable of damaging adjacent cells, lipoproteins, and other structural components of the skin's extracellular matrix, such as collagen and elastin. Other NOX categories include tumor-NOX, viral-NOX and constitutive, or normal, NOX. About IID2008 International Investigative Dermatology 2008 is the fifth joint meeting of the Society for Investigative Dermatology (SID), the European Society for Dermatological Research (ESDR) and the Japanese Society for Investigative Dermatology (JSID). IID2008 is hosted in Kyoto, Japan, May 14-17, and is the only major venue this year for the presentation of the latest information on skin biology and skin diseases. The conference program is widely based on any of the basic and clinical dermatological fields. Nu Skin Enterprises Nu Skin Enterprises, Inc. is a global direct selling company operating in 47 markets throughout Asia, the Americas and Europe. The company markets premium-quality personal care products under the Nu Skin(R) brand, science-based nutritional supplements under the Pharmanex (R) brand, and technology-based products and services under the Big Planet(R) brand. Nu Skin Enterprises is traded on the New York Stock Exchange under the symbol "NUS." More information is available at http://www.nuskinenterprises.com. Please call me or my husband Chris at 702-942-3309 or e mail me for more information. You can also follow this link to see videos and read more about the Galvanic Spa and the soon to be released ageLOC product line. Disclaimer- These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. 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